Journal of Andrology
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Published-Ahead-of-Print November 28, 2007, DOI:10.2164/jandrol.107.004226

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Pharmacokinetics and Pharmacodynamics of Oral Testosterone Enanthate Plus Dutasteride for Four Weeks in Normal Men: Implications for Male Hormonal Contraception

John K. Amory *, Thomas F Kalhorn , and Stephanie T Page

* To whom correspondence should be addressed. E-mail: jamory{at}u.washington.edu.

Context: Oral administration of testosterone enanthate (TE) and dutasteride increases serum testosterone and might be useful for male hormonal contraception. Objective: To ascertain the contraceptive potential of oral TE and dutasteride by determining the degree of gonadotropin suppression mediated by four weeks of oral TE plus dutasteride. Study Design, Setting, Subjects and Intervention: Twenty normal young men were randomly assigned to 4 weeks of either 400 mg oral TE twice daily or 800 mg oral TE once daily, in a double-blinded, controlled fashion at a single site. All men received 0.5 mg of dutasteride daily. Outcome Measures: Blood for measurement of serum LH, FSH, T, DHT and estradiol was obtained prior to treatment, weekly during treatment, and 1, 2, 4, 8, 12, 13, 14, 16, 20 and 24 hours after the morning dose on the last day of treatment. Results: FSH was significantly suppressed throughout treatment with 800 mg TE once daily and after 4 weeks of treatment with 400 mg TE twice daily. LH was significantly suppressed after 2 weeks of treatment with 800 mg TE, but not with 400 mg TE. Serum DHT was suppressed and serum estradiol increased during treatment in both groups. HDL cholesterol was suppresed during treatment, but liver function tests, hematocrit, creatinine, mood and sexual function were unaffected. Conclusions: The administration of 800 mg of oral TE daily combined with dutasteride for 28 days significantly suppresses gonadotropins without untoward side effects and might have utility as part of a male hormonal contraceptive regimen.


Key words: Androgen • Contraception • Spermatogenesis • 5-alpha-reductase • FSH • LH






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