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Published-Ahead-of-Print January 24, 2008, DOI:10.2164/jandrol.107.003731

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The Metabolic Syndrome and Male Infertility

Sanjay S. Kasturi , Justin Tannir , and Robert E. Brannigan *

* To whom correspondence should be addressed. E-mail: r-brannigan{at}northwestern.edu.

Metabolic syndrome (MetS) is highly prevalent, affecting over 47 million US residents. This condition is also multi-faceted, potentially leading to significant disturbance of numerous physiological processes. This review article evaluates the literature regarding metabolic syndrome and male reproductive health. Links between obesity, dyslipidemia, hypertension, and insulin resistance are each examined with regard to their associated detrimental effects on male fertility. At the end of this manuscript, we propose a new MetS/Male Infertility paradigm. Additional studies specifically addressing the components of MetS and their impact on male reproduction will enhance our understanding of the underlying pathophysiology. These studies may also help clarify the role for therapeutic intervention.


Key words: Infertility • Reproductive Tract • Diabetes Mellitus • Hyperlipidemia • Metabolic Syndrome






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