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Published-Ahead-of-Print August 1, 2007, DOI:10.2164/jandrol.107.003046

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The influence of oxidative damage on viscosity of seminal fluid in infertile men

birsen aydemir *, ilhan onaran , ali riza kiziler , bulent alici , and mehmet can akyolcu

* To whom correspondence should be addressed. E-mail: birsenay2001{at}yahoo.com.

Oxidative damage has been suggested to play an important role in the viscosity changes of human blood. Although the physical and chemical properties of human semen are completely different from that of blood, oxidative damage may also effect seminal fluid viscosity. However, changes in levels of oxidative damage products in semen and their relationship to seminal fluid viscosity are unknown. The aim of our study was to investigate whether oxidative damage was associated with increased seminal plasma viscosity in infertile subjects. The levels of malondialdehyde (MDA) and protein carbonyls were measured in sperm and seminal plasma from 102 individuals including 60 infertile patients. Seminal fluid viscosity and semen visco elasticity were assessed using capillary viscometry and glass pipetes, respectively. Significantly higher levels of oxidative damage markers were found in the infertile subjects compared to the control subjects. The seminal fluid viscosities of infertile patients were found to be significantly higher than in the control group, although semen visco-elasticity was normal in all of the control and infertile subjects. Using Pearson correlation analysis, we found significant positive correlations between seminal fluid viscosity, and seminal plasma MDA and protein carbonyl levels in infertile males (r= 0.676, p<0.01; r= 0.276, p<0.05, respectively). These findings indicate that seminal fluid viscosity is influenced by the oxidative damage products in the seminal plasma. Therefore, our results suggest that increased oxidative damage might be a factor contributing to the hyper-viscosity of seminal plasma in infertile males.


Key words: Infertility • Reactive Oxygen • Semen • Semen Analysis • Sperm • malondialdehyde • protein carbonyls • viscosity




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 Hum Reprod UpdateHome page
K. Tremellen
Oxidative stress and male infertility--a clinical perspective
Hum. Reprod. Update, May 1, 2008; 14(3): 243 - 258.
[Abstract] [Full Text] [PDF]


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