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Published-Ahead-of-Print October 3, 2007, DOI:10.2164/jandrol.107.002774

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A Dose Response Study of Testosterone on Sexual Dysfunction and on Features of the Metabolic Syndrome Using Testosterone Gel and Parenteral Testosterone Undecanoate

Farid Saad *, Louis J Gooren , Ahmad Haider , and Aksam Yassin

* To whom correspondence should be addressed. E-mail: farid.saad{at}bayerhealthcare.com.

Objective: To study the dose responses of testosterone (T) treatment on sexual dysfunction and the metabolic syndrome two cohorts of elderly men with late onset hypogonadism were followed over 9 months. Patients & methods: Group 1 (28 men; mean age 61 yrs; mean T 2.07 ± 0.50 ng/ml) received the long acting T undecanoate (1000 mg. Group 2 (27 men, mean age 60 yrs, mean T 2.24 ± 0.41) received T gel (50 mg/day) for 9 months. Results: (* statistical significance) With T gel plasma T rose from 2.24 ± 0.41 to 2.95 ± 0.52* at 3 mo, to 3.49 ± 0.89* at 6 mo, to 3.80 ± 0.73 at 9 mo (T at 6 mo* compared to T at 3 mo). With TU plasma T rose from 2.08 ± 0.56 to 4.81 ± 0.83* at 3 mo, to 5.29 ± 0.91 at 6 mo, to 5.40 ± 0.77 at 9 mo. With TU administration plasma T was *higher than with T gel. With TU there was a larger improvement of sexual symptoms (International Index of Erectile Function) and on parameters of the metabolic syndrome. With both treatments, changes in waist circumferences correlated with changes in cholesterol, LDL and HDL. Parameters of safety were not different. Conclusion: T administration has a beneficial effect on sexual dysfunction and on features of the metabolic syndrome in elderly men. The higher plasma levels of T generated with TU than with T gel (50 mg/day) were clearly more effective indicating that there is a plasma level of T / effect relationship.


Key words: Androgen • Andropause • Erectile Dysfunction • Prostate • metabolic syndrome • sex hormone binding globulin




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