Journal of Andrology
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Published-Ahead-of-Print January 10, 2007, DOI:10.2164/jandrol.106.001529

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Decreased semen volume and spermatozoa motility in HIV-1 infected patients under antiretroviral treatment

Louis BUJAN *, Martin SERGERIE , Nathalie MOINARD , Stéphanie MARTINET , Lydie PORTE , Patrice MASSIP , Christophe PASQUIER , and Myriam DAUDIN

* To whom correspondence should be addressed. E-mail: bujan.l{at}chu-toulouse.fr.

Inconsistent results were reported on semen quality in HIV-infected men, due to several bias in some studies. The objective of this study is to investigate semen parameters in HIV-1 infected patients and to compare their sperm characteristics with those of a control group of fertile non-infected men. Factors implicated in semen alterations in HIV-1 patients were also analyzed. One hundred and ninety HIV-infected men, of whom 91% were under antiretroviral therapy, and 218 fertile men were studied. Infertility risk factors were recorded and clinical examination was done in both groups. Records of HIV-infection history, antiretroviral treatment, and HIV-1 RNA detection in blood as well as HIV-1 genome detection in semen were obtained in infected patients. Semen volume, percentage of progressive motile spermatozoa, total sperm count and polynuclear cell count, were decreased while pH value and spermatozoa multiple anomaly index were increased in HIV-infected patients. Even after adjustment for possible sources of bias, the decrease in semen volume and progressive motility and the increase in pH remained significant. In conclusion this study demonstrated sperm motility and ejaculate volume alterations in HIV-1 infected patients, most of whom were receiving antiretroviral therapy. In HIV-1 patients, further longitudinal studies are required in order to analyze the responsibility of treatment regimen on sperm parameters alterations.


Key words: Assisted reproduction • Reproductive Tract • Semen • Sperm • Infectious desease HIV




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[Abstract] [Full Text] [PDF]


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Copyright © 2007 by The American Society of Andrology.