Journal of Andrology Download to Citation Manager
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published-Ahead-of-Print October 4, 2006, DOI:10.2164/jandrol.106.001313

This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
28/2/223    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Padmanabhan, P.
Right arrow Articles by McCullough, A. R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Padmanabhan, P.
Right arrow Articles by McCullough, A. R

Penile Oxygen Saturation (StO2) in the Flaccid and Erect Penis in Men With and Without Erectile Dysfunction (ED)

Priya Padmanabhan and Andrew R McCullough *

* To whom correspondence should be addressed. E-mail: andy.mccullough{at}nyumc.org.

ABSTRACT It is believed that a chronic state of corporal oxygen desaturation or hypoxemia secondary to the loss of nocturnal erections is a fundamental pathophysiological cause of erectile dysfunction (ED). Limited invasive blood gas measurements in human models have shown decreased oxygen tension in vasculogenic impotence. Normative data on flaccid and erect oxygen saturation levels are lacking due to the invasive nature of blood gas determinations. Our objective was to determine oxygen saturation (StO2) in the flaccid and erect penis in men with and without ED using a tissue oximeter. This FDA-approved instrument provides instantaneous, non-invasive painless local tissue StO2 measurements which highly correlates to blood gas data. The study population included 171 men (18 - 90 years) who presented to one andrologist. They completed the Sexual Health Inventory for Men (SHIM) based on pharmacologically unassisted erectile function and had penile StO2 measurements taken. 64 of these men had repeat measurements after PGE-1 induced erections. There are significant differences (p<0.001) in corporal and glanular StO2 in the flaccid (right corpora 45.23%, left corpora 52.50%) and erect state (right corpora 76.58, left corpora 80.42). Men with ED (right corpora 45.04% vs. 53.58%, p= 0.02 and left corpora 50.95% vs. 58.78%, p= 0.03) have significantly lower corporal penile StO2 . Future prospective data collection can correlate penile StO2 in specific populations, such as diabetics and RRP patients. This may help further elucidate the relationship between corporal hypoxia and the development, progression of ED and possibly its treatment and prevention. This work was support by an unrestricted investigator research grant from Pfizer Pharmaceuticals. The Odissey Machine was provided by Vioptix


Key words: Erectile Dysfunction • Penis • Penile oxymetry • Tissue oximeter




This article has been cited by other articles:


Home page
 J AndrolHome page
A. M. Traish, A. Guay, R. Feeley, and F. Saad
The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunction
J Androl, January 1, 2009; 30(1): 10 - 22.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by The American Society of Andrology.