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Published-Ahead-of-Print July 26, 2006, DOI:10.2164/jandrol.106.000661

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The effect of {alpha}-adrenergic antagonists in chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis of randomized controlled trials

Gang Yang , Qiang Wei , Hong Li , Yuru Yang , Sixiao Zhang , and Qiang Dong *

* To whom correspondence should be addressed. E-mail: dqiang{at}gmail.com.

The effectiveness of {alpha}-adrenergic antagonists on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has not been supported by well evaluated. The meta-analysis was performed to supply the best evidence about use of this class of drugs in CP/CPPS. A fully recursive literature search to June 2005 was conducted in PubMed, EMBASE, Cochrane Controlled Trials Register and Chinese Biomedicine Database to identify potentially relevant randomized controlled trials. RevMan4.2 was used for statistical analysis. Nine studies with 734 patients were included. Combined analysis showed a significant reduction of total NIH-CPSI or I-PSS in patients with treatment duration more than 3 months. There were also valuable results in urinary symptoms alleviation. {alpha}-adrenergic antagonists did not show benefit in pain. The meta-analysis revealed that the use of {alpha}-adrenergic antagonists was warranted in CP/CPPS, and the treatment duration should be long enough (more than 3 months).


Key words: chronic prostatitis • chronic pelvic pain syndrome • a-adrenergic antagonists




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[Abstract] [Full Text] [PDF]


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