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Published-Ahead-of-Print February 1, 2006, DOI:10.2164/jandrol.05163

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Role of peripheral innervation in p-chloroamphetamine (PCA)-induced ejaculation in anethetized rats

Pierre Clement , Hossein K. Kia , Stephane Droupy , Jacques Bernabe , Laurent Alexandre , Pierre Denys , and Francois Giuliano

The occurrence of ejaculation, which consists of two distinct phases (emission and expulsion), requires a tight coordination of peripheral autonomic and somatic nerves. However some aspects of the mechanism of ejaculation are not clearly defined. To clarify this issue, we used the p-chloroamphetamine (PCA)-induced ejaculation model in anesthetized rats and investigated the effects of selective peripheral nerves lesions on seminal vesicle and bulbospongiosus muscles (BS) activities as representing physiological markers of emission and expulsion phases respectively. In intact rats, PCA (i.p., 5 mg/kg) induced ejaculation correlated with coordinated increases in seminal vesicle pressure (SVP) and BS electromyographic activity. PCA-induced ejaculation was still observed in rats with bilateral lesion of hypogastric nerves (HNx), lumbar paravertebral sympathetic chain (LSCx), or dorsal nerves of the penis (DNPx). Conversely, bilateral section of pelvic nerves (PNx) or L6-S1 dorsal roots (DRx) abolished PCA-induced ejaculation. The amplitude of SVP increases induced by PCA was reduced in PNx, HNx, and LSCx rats whereas it was unchanged in DRx and DNPx animals. The time interval between SVP increases and BS contractions induced by PCA was comparable in the different neural lesion groups. In conclusion PCA initiates both emission and expulsion independently from each other. In this model, afferents conveyed by the pelvic nerves appear not necessary for occurrence of BS contractions but are essential for a complete ejaculatory response.






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