Journal of Andrology Cross-Journal Searching
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahmad, N.
Right arrow Articles by Warren, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahmad, N.
Right arrow Articles by Warren, D. W.

Journal of Andrology, Vol 4, Issue 1 82-87, Copyright © 1983 by The American Society of Andrology

JOURNAL ARTICLE

Testosterone metabolism by testicular tissue

N. Ahmad and D. W. Warren

Teased testicular tissue with defined cell populations from experimental rats, as well as testicular tissue from normal rats, was incubated in an environment that insured the morphologic integrity of the tissue at the conclusion of the experiment. In cryptorchid animals, conversion of available substrate to various metabolites by testicular tissue comprised of Leydig and Sertoli cells was comparable to that of intact controls. Using hypophysectomized and hypophysectomized-cryptorchid rats, reliably measurable androgen metabolites were produced by testicular tissue that had specific populations of intact cell types. The reported methodology shows that defined cell populations, capable of testosterone metabolism, can be obtained in vivo by surgical procedures. Histologic monitoring of the tissue at the conclusion of the incubation has helped define the best environment for the maintenance of morphologic integrity throughout the incubation period. These techniques will allow future work on quantitative assessment of testosterone metabolism by defined cell populations of the testis.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by The American Society of Andrology.