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1 Department of Physiology,
Georgetown University Medical Center,
Washington, D. C.
In order to examine the possible role of androgens in
the isotonic response of the isolated rat aorta, a highly
active mimic of thromboxane was employed. The
maximum response to this TXA2-mimic U46619 was
greater by 24 ± 3% (P < 0.01) in the male, as compared
with the female. In addition, the sensitivity of the male
vessel was 35 ± 4% greater than that of the female vessel (P < 0.01). Orchiectomy decreased the maximum
contractile response to the TXA2-mimic; however,
ovariectomy increased both the maximum response and
sensitivity. Testosterone pretreatment (1 mg/kg intramuscularly, biweekly for two weeks) restored the response of the castrated male but did not further increase
the response of the ovariectomized female. The
maximum response and sensitivity of the aorta of the
intact female pretreated with testosterone was increased
(P < 0.01). These results suggest that the response of rat
aorta to a TXA2-mimic may be regulated not only by
androgens, but also by ovarian hormones.
Key words: castration, androgen-treatment, vascular reactivity, thromboxane-mimic
Submitted on January 18, 1982
Revised on March 22, 1982
Accepted on April 13, 1982
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  J. N. Stallone, R. L. Salisbury, and C. T. Fulton Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta J Appl Physiol, December 1, 2001; 91(6): 2602 - 2610. [Abstract] [Full Text] [PDF]
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