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Journal of Andrology, Vol 3, Issue 1 69-71, Copyright © 1982 by The American Society of Andrology

In Vitro Effect of Inhibin on Cyclic AMP-Phosphodiesterase Activity in Rat Testes

ANIL R. SHETH 1, S. VIJAYALAKSHMI 1, PARUL R. SHETH 1, A. H. BANDIVDEKAR 1, AND SUDHIR B. MOODBIDRI 1

1 Institute for Research in Reproduction (ICMR), Parel, Bombay, India

We have previously reported that incubation of testicular slices with inhibin in the presence of 6 x 10-8 M oFSH resulted in a dose-related reduction in accumulation of cyclic AMP due to a decrease in adenyl cyclase activity. The present study demonstrates that inhibin enhances the cyclic AMP-phosphodiesterase activity in rat testicular tissue. These results suggest an additional mechanism by which cyclic AMP levels in gonadal tissue could be regulated by inhibin.

     Key words: inhibin, cyclic AMP-phosphodiesterase

Submitted on July 14, 1980
Revised on March 18, 1981
Accepted on May 1, 1981






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Copyright © 1982 by The American Society of Andrology.