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Intrauterine Insemination With Double Ejaculate Compared With Single Ejaculate in Male Factor Infertility: A Pilot Study

ERAN SOZEN

BURCU BULUC

From the ^* GATA School of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey; and the Ankara ART Center, Turkey.

Correspondence to: Dr Tansu Küçük, Professor, Lecturer, GATA School of Medicine, Department of Obstetrics and Gynecology, 06018, Etlik, Ankara, Turkey (e-mail: tansukucuk{at}gmail.com).

The aim of this study was to compare the efficiency of using a double ejaculate with the efficiency of using a single ejaculate for intrauterine insemination in male subfertility. Eligibility for the study was a total motile sperm count between 1 x 10⁶ and 5 x 10⁶ on postwash sperm analysis. Thirty-nine couples were randomized to the study group, while another 50 couples were randomized to serve as the control group. Males in the study group were asked to produce a second semen sample within 2 hours of the first sample on the day of insemination. In the study group, the mean total motile sperm count in the first sample was 3.83 x 10⁶ (SD ± 0.85 x 10⁶; range 1.1–4.9) and 3.99 x 10⁶ (SD ± 0.72 x 10⁶; range 0.9–4.4) in the control group. The mean total motile sperm count in the second sample was 3.52 x 10⁶ (SD ± 1.46 x 10⁶; range 0.9–3.7) in the study group. The mean total motile sperm count in the final inseminate was 7.35 x 10⁶ (SD ± 1.90 x 10⁶; range 2.9–10.6) in the study group. The difference in total motile sperm counts between the study and the control group was statistically significant (P < .001). There were 6 pregnancies in the study group, providing a pregnancy rate of 15.3%, whereas there were 5 pregnancies in the control group, representing a pregnancy rate of 10% (P = .44). We concluded that although it does not increase the pregnancy rate significantly, obtaining a second semen sample when the motile sperm yield of the first semen sample is 1 million to 5 million significantly increases the total motile sperm count in the final inseminate.

     Key words: Total motile sperm count, IUI, inseminate, second ejaculate