Journal of Andrology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Journal of Andrology, Vol. 26, No. 4, July/August 2005
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.04104

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Owen, D. H.
Right arrow Articles by Katz, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Owen, D. H.
Right arrow Articles by Katz, D. F.

A Review of the Physical and Chemical Properties of Human Semen and the Formulation of a Semen Simulant

DEREK H. OWEN* AND DAVID F. KATZ*,{dagger}

From the * Department of Biomedical Engineering and the {dagger} Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.

Correspondence to: Dr Derek H. Owen, Department of Biomedical Engineering, Duke University, Box 90281, Durham, NC 27708 (e-mail: dhowen{at}duke.edu).


A fluid medium was developed to simulate the salient physical and chemical properties of human semen. The composition of the medium was based upon an extensive review of the literature on constituents of human semen. In choosing the ingredients for this medium, the goal was to emphasize properties that influence interactions of human semen with topical contraceptive, prophylactic, or therapeutic products. Among these properties, pH and buffering capacity, osmolarity, ionic strength, and rheological properties play dominant roles in the physico-chemical processes that govern drug release kinetics and delivery vehicle distribution.

     Key words: Composition, human, semen, simulant, microbicide




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. M. L. Edstrom, J. Malm, B. Frohm, J. A. Martellini, A. Giwercman, M. Morgelin, A. M. Cole, and O. E. Sorensen
The Major Bactericidal Activity of Human Seminal Plasma Is Zinc-Dependent and Derived from Fragmentation of the Semenogelins
J. Immunol., September 1, 2008; 181(5): 3413 - 3421.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
C. Lackman-Smith, C. Osterling, K. Luckenbaugh, M. Mankowski, B. Snyder, G. Lewis, J. Paull, A. Profy, R. G. Ptak, R. W. Buckheit Jr., et al.
Development of a Comprehensive Human Immunodeficiency Virus Type 1 Screening Algorithm for Discovery and Preclinical Testing of Topical Microbicides
Antimicrob. Agents Chemother., May 1, 2008; 52(5): 1768 - 1781.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Sabatte, A. Ceballos, S. Raiden, M. Vermeulen, K. Nahmod, J. Maggini, G. Salamone, H. Salomon, S. Amigorena, and J. Geffner
Human Seminal Plasma Abrogates the Capture and Transmission of Human Immunodeficiency Virus Type 1 to CD4+ T Cells Mediated by DC-SIGN
J. Virol., December 15, 2007; 81(24): 13723 - 13734.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. L. Russo, S. Spurr-Michaud, A. Tisdale, J. Pudney, D. Anderson, and I. K. Gipson
Mucin gene expression in human male urogenital tract epithelia
Hum. Reprod., November 1, 2006; 21(11): 2783 - 2793.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
A. R. Geonnotti and D. F. Katz
Dynamics of HIV Neutralization by a Microbicide Formulation Layer: Biophysical Fundamentals and Transport Theory
Biophys. J., September 15, 2006; 91(6): 2121 - 2130.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by The American Society of Andrology.