Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rosas-Vargas, H.
Right arrow Articles by Salamanca, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rosas-Vargas, H.
Right arrow Articles by Salamanca, F.
Journal of Andrology, Vol. 25, No. 5, September/October 2004
Copyright © American Society of Andrology

Glu298Asp Endothelial Nitric Oxide Synthase Polymorphism Is a Risk Factor for Erectile Dysfunction in the Mexican Mestizo Population

HAYDEE ROSAS-VARGAS*, RAMON M. CORAL-VAZQUEZ*, ROSARIO TAPIA{dagger}, JOSE L. BORJA*, RICARDO A. SALAS{dagger} AND FABIO SALAMANCA*

From the * Unidad de Investigacion Medica en Genetica Humana, Hospital de Pediatria; and {dagger} Sección de Andrología, Hospital de Especialidades, Centro Medico Nacional Siglo XXI-IMSS, Mexico, D.F., Mexico.

Correspondence to: Haydee Rosas-Vargas, Unidad de Investigacion Medica en Genetica Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI-IMSS, Av Cuauhtemoc No 330, Col Doctores, Delegacion Cuauhtemoc. 06725 Mexico, D.F., Mexico (e-mail: hayrov{at}hotmail.com).


Penile erection depends on the balanced action between antagonist vasoactive molecules such as nitric oxide (NO) and angiotensin. Endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) polymorphisms have been associated with endothelial dysfunction, which is described as a cause of erectile dysfunction (ED). Endothelial NOS and ACE are both regulators of vascular and corporal smooth muscle tone, which are connected by interaction between the NO-cyclic guanosine monophosphate pathway and the renin-angiotensin system. We analyzed the frequencies of 894 G/T (Glu298Asp) eNOS and ACE I/D polymorphisms in Mexican patients with ED (n = 53) and in an age-matched control group (n = 62). The populations analyzed were in Hardy Weinberg equilibrium. We found significant differences in allelic ({chi}2 = 4.42; P = .03) and genotypic frequencies ({chi}2 = 3.96; P = .04) between patients and controls for the 894 G/T eNOS polymorphism. Presence of the 894T allele in carriers increased the risk of ED (odds ratio [TT + GT versus GG] = 2.37; 95% confidence interval, 1.08 to 5.21; P = .02). Multiple logistic regression analysis showed that the Glu298Asp polymorphism was an independent factor for ED, as was diabetes mellitus, hypertension, cardiac disease, and cigarette smoking. No association was found between ACE I/D polymorphism and ED in the population studied. Therefore, our results suggest that Glu298Asp eNOS polymorphism plays a role as a genetic susceptibility factor for ED.

     Key words: Angiotensin-converting enzyme, endothelial dysfunction, impotence




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
C. S. Saigal, H. Wessells, J. Pace, M. Schonlau, T. J. Wilt, and for the Urologic Diseases in America Project
Predictors and Prevalence of Erectile Dysfunction in a Racially Diverse Population
Arch Intern Med, January 23, 2006; 166(2): 207 - 212.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by The American Society of Andrology.