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Abundance of Repetitive Sequence Elements in the Mouse Testis-Specific Lactate Dehydrogenase-C Gene¹

HIROSHI TSUJIOKA

SONOKO NARISAWA

ERWIN GOLDBERG

JOSÉ LUIS MILLÁN^*,

From the ^* Department of Medical Biosciences, Medical Genetics, Umeå University, Umeå, Sweden; The Burnham Institute, La Jolla, California; and the Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois.

Correspondence to: Dr José Luis Millán, The Burnham Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037 (e-mail: millan{at}burnham.org).

We have cloned and sequenced the entire mouse ldhc gene and mapped it physically in relation to the somatic ldha gene. The 2 genes were found to be oriented in head-to-tail fashion with about a 6-kilobase (kb) distance between the 3' end of ldha and the 5' end of ldhc. The ldhc gene is composed of 43% repetitive elements compared to only 16% in the ldha gene. Despite the close physical distance of mouse ldha and ldhc, the 2 genes have a very different content of repetitive elements, and this most likely reflects different levels of selective pressure.

     Key words: Isozyme, restriction maps