Journal of Andrology Cross-Journal Searching
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Turner, K. O.
Right arrow Articles by Meizel, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Turner, K. O.
Right arrow Articles by Meizel, S.

Journal of Andrology, Vol 18, Issue 6 571-575, Copyright © 1997 by The American Society of Andrology

JOURNAL ARTICLE

The human acrosome reaction is highly sensitive to inhibition by cyclodiene insecticides

K. O. Turner, M. Syvanen and S. Meizel
Department of Cell and Human Anatomy, School of Medicine, University of California, Davis 95616-8643, USA.

The mammalian sperm acrosome reaction (AR) is essential to fertilization. It can be initiated in vitro by progesterone, a putative physiological initiator that helps to activate sperm GABA(A) receptor/chloride channels and by glycine, a substitute for the egg zona pellucida, which activates sperm glycine receptor/chloride channels. Even at 1 nM (0.41 ng/ml or 0.41 ppb), chlordane and endosulfan, chlorinated cyclodiene blockers of insect neuronal GABA(A) receptor/chloride channels, strongly inhibited the AR initiated by progesterone or glycine. Inhibition of the latter was also seen at 0.1 nM chlordane and endosulfan, but neither cyclodiene inhibited either AR initiator at 0.01 nM. Inhibitory concentrations of these cyclodienes are well within the range detected in human and wildlife tissue and fluids as a result of environmental contamination.


This article has been cited by other articles:


Home page
 J AndrolHome page
J. C. Kirkman-Brown, E. L. Punt, C. L. R. Barratt, and S. J. Publicover
Zona Pellucida and Progesterone-Induced Ca2+ Signaling and Acrosome Reaction in Human Spermatozoa
J Androl, May 1, 2002; 23(3): 306 - 315.
[Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
T. D. Sutherland, I. Horne, M. J. Lacey, R. L. Harcourt, R. J. Russell, and J. G. Oakeshott
Enrichment of an Endosulfan-Degrading Mixed Bacterial Culture
Appl. Envir. Microbiol., July 1, 2000; 66(7): 2822 - 2828.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by The American Society of Andrology.