Journal of Andrology Free Medline Services
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blanco-Rodriguez, J.
Right arrow Articles by Martinez-Garcia, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blanco-Rodriguez, J.
Right arrow Articles by Martinez-Garcia, C.

Journal of Andrology, Vol 18, Issue 5 535-539, Copyright © 1997 by The American Society of Andrology

JOURNAL ARTICLE

Mild hypothermia induces apoptosis in rat testis at specific stages of the seminiferous epithelium

J. Blanco-Rodriguez and C. Martinez-Garcia
Department of Cell Biology, Valladolid University, School of Medicine, Spain.

This study was designed to determine the effects of short episodes of mild hypothermia on cell apoptosis in the testis of the adult rat. Apoptosis was assessed by in situ DNA 3'-end labeling in the testes from rats killed 2 hours after cooling (10 degrees C for 30 minutes), quantitated, and compared with spontaneous apoptosis found in control animals. A significantly increased number of dying germ cells appeared after cold treatment at specific stages (stage XIV, P < 0.0001; stage XII, P < 0.001) of the seminiferous epithelium, mainly due to dying primary metaphasic spermatocytes (P < 0.0001), followed by secondary interphase spermatocytes (P < 0.001), and A2 spermatogonia (P < 0.05). The highly specific effect of mild hypothermia on germ cell apoptosis suggests that the process is tightly regulated.


This article has been cited by other articles:


Home page
 J AndrolHome page
Z. Zhang, R.V. Short, T. Meehan, D.M. de Kretser, M.B. Renfree, and K.L. Loveland
Functional Analysis of the Cooled Rat Testis
J Androl, January 1, 2004; 25(1): 57 - 68.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Doerksen, G. Benoit, and J. M. Trasler
Deoxyribonucleic Acid Hypomethylation of Male Germ Cells by Mitotic and Meiotic Exposure to 5-Azacytidine Is Associated with Altered Testicular Histology
Endocrinology, September 1, 2000; 141(9): 3235 - 3244.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by The American Society of Andrology.