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Journal of Andrology, Vol 18, Issue 4 341-344, Copyright © 1997 by The American Society of Andrology

REVIEW

Molecular aspects of steroid hormone action in the male reproductive axis

M. A. Shupnik and D. A. Schreihofer
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA.

Both T and E play important roles in the regulation of reproductive function at the cellular and tissue levels in males. In addition to a causal role in the development of the male reproductive phenotype, androgens provide feedback regulation to the hypothalamus and to the pituitary in humans. Estrogen action is critical for normal bone fusion and mineralization in both men and women, and E action appears to play an important role in hypothalamic suppression of gonadotropin levels.




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Copyright © 1997 by The American Society of Andrology.