Journal of Andrology Cross-Journal Searching
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Teixeira, J.
Right arrow Articles by Donahoe, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Teixeira, J.
Right arrow Articles by Donahoe, P. K.

Journal of Andrology, Vol 17, Issue 4 336-341, Copyright © 1996 by The American Society of Andrology

REVIEW

Molecular biology of MIS and its receptors

J. Teixeira and P. K. Donahoe
Department of Surgery, Massachusetts General Hospital, Boston 02114, USA.

It is important, given the potential use of MIS as an anticancer agent against tumors of Mullerian duct origin, that the search continue to identify binding isoforms of the MIS type II receptor or to identify other factors in the heteromeric complex that might be required for specific binding of this ligand to be observed. With confidence in binding one can use receptor probes to screen patients with ovarian cancer and to identify those that express receptor. This subgroup can then be examined for binding of the MIS ligand and subsequently for antiproliferative response to MIS, in order to preselect candidate patients for receptor-directed MIS treatment. Thus, a once obscure phenomenon observed in the Freemartin has led to the purification and cloning of MIS and the identification of its receptor components, as well as an understanding of their regulation and expression. Elucidation of these molecular events brings us closer to the use of molecules such as MIS in the clinical setting.


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
X. Yin, S. Ouyang, W. Xu, X. Zhang, K. L. Fok, H. Y. Wong, J. Zhang, X. Qiu, S. Miao, H. C. Chan, et al.
YWK-II protein as a novel Go-coupled receptor for Mullerian inhibiting substance in cell survival
J. Cell Sci., May 1, 2007; 120(9): 1521 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Hossain and G. F. Saunders
Role of Wilms Tumor 1 (WT1) in the Transcriptional Regulation of the Mullerian-Inhibiting Substance Promoter
Biol Reprod, December 1, 2003; 69(6): 1808 - 1814.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Teixeira, S. Maheswaran, and P. K. Donahoe
Mullerian Inhibiting Substance: An Instructive Developmental Hormone with Diagnostic and Possible Therapeutic Applications
Endocr. Rev., October 1, 2001; 22(5): 657 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Teixeira, D. J. Kehas, R. Antun, and P. K. Donahoe
Transcriptional regulation of the rat Mullerian inhibiting substance type II receptor in rodent Leydig cells
PNAS, November 23, 1999; 96(24): 13831 - 13838.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Teixeira, E. Fynn-Thompson, A. H. Payne, and P. K. Donahoe
Mullerian-Inhibiting Substance Regulates Androgen Synthesis at the Transcriptional Level
Endocrinology, October 1, 1999; 140(10): 4732 - 4738.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
P. d. S. Barbara, B. Moniot, F. Poulat, B. Boizet, and P. Berta
Steroidogenic Factor-1 Regulates Transcription of the Human Anti-mullerian Hormone Receptor
J. Biol. Chem., November 6, 1998; 273(45): 29654 - 29660.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. B. Draper, M. M. Matzuk, V. J. Roberts, E. Cox, J. Weiss, J. P. Mather, and T. K. Woodruff
Identification of an Inhibin Receptor in Gonadal Tumors from Inhibin alpha -Subunit Knockout Mice
J. Biol. Chem., January 2, 1998; 273(1): 398 - 403.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. A. Catlin, V. C. Tonnu, R. G. Ebb, B. A. Pacheco, T. F. Manganaro, R. M. Ezzell, P. K. Donahoe, and J. Teixeira
Mullerian Inhibiting Substance Inhibits Branching Morphogenesis and Induces Apoptosis in Fetal Rat Lung
Endocrinology, February 1, 1997; 138(2): 790 - 796.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. L. Segev, T. U. Ha, T. T. Tran, M. Kenneally, P. Harkin, M. Jung, D. T. MacLaughlin, P. K. Donahoe, and S. Maheswaran
Mullerian Inhibiting Substance Inhibits Breast Cancer Cell Growth through an NFkappa B-mediated Pathway
J. Biol. Chem., September 8, 2000; 275(37): 28371 - 28379.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. U. Ha, D. L. Segev, D. Barbie, P. T. Masiakos, T. T. Tran, D. Dombkowski, M. Glander, T. R. Clarke, H. K. Lorenzo, P. K. Donahoe, et al.
Mullerian Inhibiting Substance Inhibits Ovarian Cell Growth through an Rb-independent Mechanism
J. Biol. Chem., November 17, 2000; 275(47): 37101 - 37109.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. M. Trbovich, P. M. Sluss, V. M. Laurich, F. H. O'Neill, D. T. MacLaughlin, P. K. Donahoe, and J. Teixeira
Mullerian Inhibiting Substance lowers testosterone in luteinizing hormone-stimulated rodents
PNAS, March 13, 2001; 98(6): 3393 - 3397.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. L. Segev, Y. Hoshiya, M. Hoshiya, T. T. Tran, J. L. Carey, A. E. Stephen, D. T. MacLaughlin, P. K. Donahoe, and S. Maheswaran
Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo
PNAS, January 8, 2002; 99(1): 239 - 244.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by The American Society of Andrology.