| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Andrology, Vol 14, Issue 6 448-455, Copyright © 1993 by The American Society of Andrology
JOURNAL ARTICLE |
K. L. Joyce, J. Porcelli and P. S. Cooke
Department of Veterinary Biosciences, University of Illinois, Urbana 61801.
Male rats made hypothyroid during neonatal life show unprecedented increases in adult testis size and daily sperm production (DSP). To determine if this effect was unique to the rat or could also be demonstrated in other species, we examined the effects of neonatal treatment with the reversible goitrogen 6-propyl-2-thiouracil (PTU) on adult testis size and function in the mouse. Male Swiss-Webster mice were untreated (control) or given PTU by adding 0.1% (w/v) to their mother's water from birth to day 25 postpartum. All pups were then weaned and given no further treatment. Sertoli cell proliferation was examined using tritiated thymidine autoradiography in some control and treated mice at 0, 5, 10, 15, 20, and 25 days, while the remainder were killed at 90 days to determine a variety of reproductive parameters. Neonatal PTU treatment decreased growth; body weight of treated mice at 4 weeks of age was 57% less than controls. Treated mice grew rapidly following cessation of PTU treatment, although their weights never equalled controls, remaining 17% smaller at 90 days of age. At 90 days of age, testis weight and DSP were increased by approximately 30% and 50%, respectively, in PTU-treated mice compared to controls. Despite the increased testis weight and function, serum testosterone concentrations were not different in control and treated mice. Testicular and epididymal histology in treated mice was similar to controls, while epididymal sperm in treated mice were motile and morphologically normal. Sertoli cell proliferation was altered in treated mice.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
 |
|
 |
|
  M. S. Wagner, S. M. Wajner, and A. L. Maia The role of thyroid hormone in testicular development and function J. Endocrinol., December 1, 2008; 199(3): 351 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Holsberger, S. E. Kiesewetter, and P. S. Cooke Regulation of Neonatal Sertoli Cell Development by Thyroid Hormone Receptor {alpha}1 Biol Reprod, September 1, 2005; 73(3): 396 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Holsberger, G. M. Buchold, M. C. Leal, S. E. Kiesewetter, D. A. O'Brien, R. A. Hess, L. R. Franca, H. Kiyokawa, and P. S. Cooke Cell-Cycle Inhibitors p27Kip1 and p21Cip1 Regulate Murine Sertoli Cell Proliferation Biol Reprod, June 1, 2005; 72(6): 1429 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Nonneman, G. A. Rohrer, T. H. Wise, D. D. Lunstra, and J. J. Ford A Variant of Porcine Thyroxine-Binding Globulin Has Reduced Affinity for Thyroxine and Is Associated with Testis Size Biol Reprod, January 1, 2005; 72(1): 214 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Walker Molecular Mechanisms Controlling Sertoli Cell Proliferation and Differentiation Endocrinology, September 1, 2003; 144(9): 3719 - 3721. [Full Text] [PDF]
|
|
|
|
|
|
D. R. Holsberger, S. Jirawatnotai, H. Kiyokawa, and P. S. Cooke Thyroid Hormone Regulates the Cell Cycle Inhibitor p27Kip1 in Postnatal Murine Sertoli Cells Endocrinology, September 1, 2003; 144(9): 3732 - 3738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Foote Effect of High-Dose Liothyronine on Semen Quality and Recovery Following Withdrawal in Rabbits J Androl, November 1, 2002; 23(6): 839 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Chiao, W.-L. Cho, and P. S. Wang Inhibition of Testosterone Production by Propylthiouracil in Rat Leydig Cells Biol Reprod, August 1, 2002; 67(2): 416 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. P. Matta, D. A. R. Vilela, H. P. Godinho, and L. R. Franca The Goitrogen 6-n-Propyl-2-Thiouracil (PTU) Given during Testis Development Increases Sertoli and Germ Cell Numbers per Cyst in Fish: The Tilapia (Oreochromis niloticus) Model Endocrinology, March 1, 2002; 143(3): 970 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.A. Thayer, R.L. Ruhlen, K.L. Howdeshell, D.L. Buchanan, P.S. Cooke, D. Preziosi, W.V. Welshons, J. Haseman, and F.S. vom Saal Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17{{alpha}}-ethinyl oestradiol Hum. Reprod., May 1, 2001; 16(5): 988 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. França, V. A. Silva Jr., H. Chiarini-Garcia, S. K. Garcia, and L. Debeljuk Cell Proliferation and Hormonal Changes During Postnatal Development of the Testis in the Pig Biol Reprod, December 1, 2000; 63(6): 1629 - 1636. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. W. Crissman, P. S. Cooke, R. A. Hess, M. S. Marty, and A. B. Liberacki Postulated Human Sperm Count Decline May Involve Historic Elimination of Juvenile Iodine Deficiency: A New Hypothesis with Experimental Evidence in the Rat Toxicol. Sci., February 1, 2000; 53(2): 400 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Teerds, D. G. de Rooij, F. H. de Jong, and L. H. van Haaster Development of the Adult-Type Leydig Cell Population in the Rat Is Affected by Neonatal Thyroid Hormone Levels Biol Reprod, August 1, 1998; 59(2): 344 - 350. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
