Journal of Andrology Cross-Journal Searching
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sokol, R. Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sokol, R. Z.

Journal of Andrology, Vol 11, Issue 6 521-526, Copyright © 1990 by The American Society of Andrology

JOURNAL ARTICLE

The effect of duration of exposure on the expression of lead toxicity on the male reproductive axis

R. Z. Sokol
Department of Medicine, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90524.

This study assesses the significance of duration of exposure on the expression of lead toxicity on the male reproductive system. Male Wistar rats, 52 days old, were treated with 0.0% or 0.6% lead acetate in their water for 7, 14, 30, or 60 days prior to sacrifice. In all cases, the lead-treated groups had blood lead and free erythrocyte protoporphyrin (FEP) levels significantly higher than control animals (P less than 0.0001). Serum testosterone levels and spermatogenesis were suppressed in all lead-treated groups compared to the corresponding controls (P less than 0.05 and P less than 0.001, respectively), except for the group treated for 7 days. The data presented verify that exposure to lead acetate is toxic to the reproductive axis in male rats, but that increased duration of exposure after 14 days does not further suppress serum testosterone levels or spermatogenesis.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
C. Y. Cheng and D. D. Mruk
Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development
Physiol Rev, October 1, 2002; 82(4): 825 - 874.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
H Bataineh, M H Al-Hamood, and A M Elbetieha
Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts
Human and Experimental Toxicology, October 1, 1998; 17(10): 570 - 576.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
G. Pinon-Lataillade, A. Thoreux-Manlay, H. Coffigny, R. Masse, and J-C. Soufir
Reproductive toxicity of chronic lead exposure in male and female mice
Human and Experimental Toxicology, November 1, 1995; 14(11): 872 - 878.
[Abstract] [PDF]

Home page
 Hum Exp ToxicolHome page
G. Pinon-Lataillade, A. Thoreux-Manlay, H. Coffigny, G. Monchaux, R. Masse, and J-C. Soufir
Effect of Ingestion and Inhalation of Lead on the Reproductive System and Fertility of Adult Male Rats and their Progeny
Human and Experimental Toxicology, January 1, 1993; 12(2): 165 - 172.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by The American Society of Andrology.