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Journal of Andrology, Vol 10, Issue 3 188-194, Copyright © 1989 by The American Society of Andrology

JOURNAL ARTICLE

Age-related changes in the concentration of cytosolic androgen receptors in the epididymis, vas deferens and seminal vesicle of maturing male mice

C. Gallon, G. Veyssiere, M. Berger, C. Jean-Faucher, M. De Turckheim and C. Jean
Physiologie Comparee et Endocrinologie, CNRS U.A. 360, Universite Blasie Pascal, Aubiere France.

In this study, changes in the number of androgen binding sites that occur in cytosols of epididymis, vas deferens and seminal vesicle of mice from 10 to 90 days of age are described. Specific saturable binding of [3H]R-1881 by cytosols of the three organs at all time points studied and age-related differences in the number of binding sites measured were observed. Cytosolic androgen receptor levels in all three organs studied were found to decrease with increasing age, regardless of whether the binding was expressed relative to weight of tissue, cytosolic protein or cellular DNA. The most pronounced change in androgen receptor levels (from 442 to 50 fmol/mg protein) was observed in the epididymis between 10 and 30 days of age. In these three organs there was no significant correlation between androgen (testosterone + dihydrotestosterone) levels and the concentration of androgen binding sites.


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Copyright © 1989 by The American Society of Andrology.