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1 School of Medicine and
Department of Physiology, Southern
Illinois University, Carbondale, Illinois
Studies were carried out to determine the effect
of various numbers of testosterone-filled
polydimethylsiloxane (PDS)capsules on
plasma concentrations of testosterone and
FSH in acutely orchidectomized dogs. Dogs
were implanted with either one empty PDS capsule or one, three, or five testosterone-filled
PDS capsules. Blood samples were collected
daily prior to implantation, following implantation, following castration, with capsules left in
situ, and following capsule removal. Replacement of testosterone, using one testosterone-filled capsule, did not prevent the postcastration rise of FSH. Replacement of testosterone,
using three and five testosterone-filled capsules, maintained both FSH and testosterone in
castrated dogs at concentrations similar to
those observed in intact animals. Removal of
testosterone-filled capsules from castrated
dogs resulted in hypersecretion of FSH. These
studies indicate that testosterone replacement
within physiologic limits will maintain FSH in
the acutely orchidectomized dogs at concentrations similar to those observed in intact, untreated animals.
Key words: testosterone, FSH, polydimethylsiloxane
Submitted on March 24, 1980
Revised on April 22, 1980
Accepted on April 23, 1980
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